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We’ve made a significant progress with our regulatory and clinical work for first line RCC and second line HCC respectively. We remain on tract to file the supplemental NDA for advance HCC later in the first quarter.I’ll spend my time today on the broader development and lifecycle management plan for cabozantinib, including combination with immune checkpoint inhibitors in collaboration with BMS and Genentech Roche. We are pleased with the progress of our clinical collaboration with BMS, combining cabozantinib with nivolumab alone, or both nivolumab and ipilimumab.I’ll start the discussion with a Phase II HCC trial, evaluating safety and preliminary activity of the cabozantinib, nivolumab and the cabozantinib, nivolumab and ipilimumab combinations in advance HCC.

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